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The crash happened along the route between the cities of Uyuni and Kolchani when one of the vehicles turned into the approaching lane.
At least 37 people have been killed and dozens of more more likely to have two buses in the western region of Potosi in Bolivia, police and local authorities said.
The incident happened Saturday at local time at 7 o'clock (11:00 GMT) along the route between the cities of Uyuni and Kolchani when one of the vehicles turned into the opposite lane.
Uyuni is the Gate to Salar de Uyuni, the main tourist attraction and the largest salt apartment in the world more than 10,000 square km (3 900 square meters).
“As a result of this fatal incident, we have 39 people wounded in four hospitals in Uyuni, and 37 people have lost their lives,” a spokesman for the Potosi Police Command told reporters.
Police staff are working to identify people who were killed and those who were injured and hospitalized, the spokesman added.
One of the buses headed to Oruro, where one of the most important carnival celebrations in Latin America is currently taking place.
Police officers removed the survivors of the steel remains, according to images captured by radio Uyuni, showing several bodies covered with blankets scattered in the high Anden planes.
A police spokesman said one of the two drivers who survived the crash was spotted by passengers consuming alcohol.
The mountain, undervalued and slightly overrated roads of Bolivia are one of the most deadly in the world, killing an average of 1,400 people every year.
